Even with Israel’s world-leading rollout of Covid-19 vaccinations, drugs to treat Covid people remain in desperate need across the world.

Two such medications developed in Israel reveal fantastic promise in scientific trials: EXO-CD24 and Allocetra.

EXO-CD24, a speculative is an inhaled medicine developed at Tel Aviv Sourasky Medical Center, was found to treat all 30 moderate-to-severe instances in a Phase I medical test.

Created over the past six months at the healthcare facility, EXOCD24 stops the “cytokine tornado” where the immune system goes out of control and also begins attacking healthy cells, this occurs in the lungs of 5-7% of Covid-19 clients.

” To date, the preparation has actually been tried with excellent success on 30 serious people, in 29 of whom the clinical problem boosted within two to three days and also the majority of them were discharged home within 3 to 5 days. The 30th individual likewise recouped however after a longer time,” the healthcare facility reports.

” The drug is based on exosomes, [vesicles] that are launched from the cell membrane and also made use of for intercellular communication. We enhance the exosomes with 24CD healthy protein. This healthy protein is expressed on the surface of the cell and also has a well-known and also crucial function in managing the body immune system,” explained Dr. Shiran Shapira, supervisor of the lab of Prof. Low point Arber, that has been investigating the CD24 healthy protein for over twenty years.

” The prep work is given by breathing, once a day, for only a few minutes, for five days,” Shapira said.

She stated the experimental therapy has two special qualities. The very first is that it prevents the over-secretion of cytokines. The second is that it is provided straight to the lungs as well as a result has no systemic negative effects that injected or dental medicines can create.

” Also if the injections perform their function, and also if no new mutations are produced then still somehow the corona will remain with us,” claimed Arber, supervisor of the clinical center’s Integrated Cancer cells Avoidance Center. “To this end, we have actually developed an unique medication, EXO-CD24.”

Arber added that this sophisticated preparation “can be created rapidly as well as efficiently and also at a very inexpensive cost  in every pharmaceutical center in the nation, as well as quickly internationally.”

Prof. Ronni Gamzu, CEO of the clinical facility, stated, “Prof. Arber’s outcomes for first-phase research were superb and also gave us all confidence in the approach he has been researching [below] for years. I directly aided him in additional acquiring the approvals from the Ministry of Health for additional research study.”


At the Same Time, Enlivex Rehab last week reported favorable arise from a multi-center Phase II professional trial of its experimental Covid-19 immunotherapy medication Allocetra in severe and critical Covid-19 individuals.

We reported in October that five Covid-19 people who had extensive treatment were discharged from Hadassah College Medical Facility in Jerusalem after treatment with Allocetra.

Nine severe and also 7 vital Covid-19 clients were treated with Allocetra in the Phase II clinical trial. Fourteen of them recovered and were discharged from the health center after an average of 5.3 days.

The Phase II trial initially was expected to enroll 24 patients but was “finished early in support of awaited faster regulatory filings of the trial’s favorable safety and security and efficiency data,” Enlivex reported.

Altogether, 19 out of 21 Phase II and also Stage Ib Allocetra test patients recovered and were discharged from the hospital after approximately 5.6 days. The majority of the clients in both research studies had pre-existing elements of concern  such as being of the male sex, excessive weight and also high blood pressure.

” The results we have seen from the 12 Covid-19 individuals treated to day with Allocetra are exciting,” said Prof. Vernon van Heerden, head of the General Intensive Care Unit at Hadassah and also the lead private investigator of both professional trials.

” The Phase II clients who have actually been released from the health center are presently healthy and balanced. Our team believe that these compelling outcomes have demonstrated the security and also efficiency of Allocetra in these complicated clients, highlighting the possibility of Enlivex’s product candidate to benefit severe as well as important Covid-19 individuals along with others suffering from cytokine tornados and organ dysfunctions across various scientific indications.”

Allocetra is based upon the research of Enlivex principal scientific and medical police officer Dr. Dror Mevorach, head of interior medicine as well as of among Hadassah’s coronavirus wards. It works by recovering balance to the immune system.

Mevorach said Allocetra “may have utility as a secure and also effective treatment … regardless of the details coronavirus anomaly that affected the individuals, and also throughout different dangerous, high death professional signs with high unmet clinical needs.”