MPs have approved Covid-19 regulations implementing three tiers of restrictions in England from Wednesday.
The vote was by 291 votes to 78, a majority of 213, and came after Labour abstained.
The decision was reached in the Commons this evening after hours of debate.
The new arrangements will come into force on Wednesday.
In total there were 53 Conservative MPs who voted against the Covid-19 restrictions.
They were joined by 15 Labour MPs, eight DUP and two independent MPs.
The restrictions will put 99 per cent of England in the toughest Tier 2 and Tier 3 restrictions.
The tiers will be reviewed every fortnight. Boris Mr Johnson has also promised MPs a fresh vote on whether to keep the entire system after February 2.
See which MPs from your area voted no:
The 53 Conservative MPs who voted against the Covid-19 restrictions were listed as: Adam Afriyie (Windsor), Imran Ahmad Khan (Wakefield), Graham Brady (Altrincham and Sale West), Andrew Bridgen (North West Leicestershire), Paul Bristow (Peterborough), Christopher Chope (Christchurch), Greg Clark (Tunbridge Wells), James Daly (Bury North), Philip Davies (Shipley), David Davis (Haltemprice and Howden), Jonathan Djanogly (Huntingdon), Jackie Doyle-Price (Thurrock), Richard Drax (South Dorset), Iain Duncan Smith (Chingford and Woodford Green), Mark Francois (Rayleigh and Wickford), Marcus Fysh (Yeovil), Cheryl Gillan (Chesham and Amersham), Chris Green (Bolton West), Damian Green (Ashford), Kate Griffiths (Burton), Mark Harper (Forest of Dean), Philip Hollobone (Kettering), David Jones (Clwyd West), Julian Knight (Solihull), Robert Largan (High Peak), Pauline Latham (Mid Derbyshire), Chris Loder (West Dorset), Tim Loughton (East Worthing and Shoreham), Craig Mackinlay (South Thanet), Anthony Mangnall (Totnes), Karl McCartney (Lincoln), Stephen McPartland (Stevenage), Esther McVey (Tatton), Huw Merriman (Bexhill and Battle), Robbie Moore (Keighley), Anne Marie Morris (Newton Abbot), Robert Neill (Bromley and Chislehurst), Mark Pawsey (Rugby), John Redwood (Wokingham), Mary Robinson (Cheadle), Andrew Rosindell (Romford), Henry Smith (Crawley), Ben Spencer (Runnymede and Weybridge), Desmond Swayne (New Forest West), Craig Tracey (North Warwickshire), Tom Tugendhat (Tonbridge and Malling), Matt Vickers (Stockton South), Christian Wakeford (Bury South), Charles Walker (Broxbourne), Jamie Wallis (Bridgend), David Warburton (Somerton and Frome), William Wragg (Hazel Grove), and Jeremy Wright (Kenilworth and Southam).
The 15 Labour MPs who ignored party orders to abstain in order to oppose the regulations were: Apsana Begum (Poplar and Limehouse), Richard Burgon (Leeds East), Mary Kelly Foy (City of Durham), Andrew Gwynne (Denton and Reddish), Mike Hill (Hartlepool), Kevan Jones (North Durham), Emma Lewell-Buck (South Shields), Ian Mearns (Gateshead), Grahame Morris (Easington), Kate Osborne (Jarrow), Bell Ribeiro-Addy (Streatham), John Spellar (Warley), Graham Stringer (Blackley and Broughton), Zarah Sultana (Coventry South), and Derek Twigg (Halton).
Former Labour Party leader Jeremy Corbyn, currently an Independent MP, also opposed the measures along with Julian Lewis (New Forest East), a former Tory sitting as an independent.
The eight DUP MPs to oppose the measures were: Gregory Campbell (East Londonderry), Jeffrey M Donaldson (Lagan Valley), Paul Girvan (South Antrim), Carla Lockhart (Upper Bann), Ian Paisley (North Antrim), Gavin Robinson (Belfast East), Jim Shannon (Strangford), and Sammy Wilson (East Antrim).
A Government spokesman welcomed MPs voting to approve the new tiered system to replace the national lockdown in England and said ministers will work with those who expressed concerns.
He said: “We welcome tonight’s vote which endorses our winter plan, brings an end to the national restrictions and returns England to a tiered system.
“This will help to safeguard the gains made during the past month and keep the virus under control.
“We will continue to work with MPs who have expressed concerns in recent days.”